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Angela M H Brodie Selected Research

Biological Products

11/2011Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.
4/2005Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
12/2004Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.

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Angela M H Brodie Research Topics

Disease

21Neoplasms (Cancer)
01/2014 - 03/2004
15Breast Neoplasms (Breast Cancer)
01/2014 - 11/2004
14Prostatic Neoplasms (Prostate Cancer)
03/2015 - 06/2003
1Carcinogenesis
11/2010
1Disease Progression
01/2008
1Thrombosis (Thrombus)
01/2007
1Osteoporosis
01/2007
1Endometrial Neoplasms (Endometrial Cancer)
01/2007

Drug/Important Bio-Agent (IBA)

12Aromatase InhibitorsIBA
01/2014 - 11/2004
10Letrozole (Femara)FDA LinkGeneric
07/2011 - 11/2004
10Estrogen ReceptorsIBA
07/2011 - 11/2004
9AndrogensIBA
11/2011 - 06/2003
9Aromatase (CYP19)IBA
07/2011 - 11/2004
7Estrogens (Estrogen)FDA Link
07/2011 - 06/2005
6Hormones (Hormone)IBA
01/2014 - 03/2004
5Androgen Receptors (Androgen Receptor)IBA
10/2011 - 10/2006
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
07/2011 - 06/2005
4TamoxifenFDA LinkGeneric
01/2007 - 11/2004
3Biological ProductsIBA
11/2011 - 12/2004
3entinostat (MS 275)IBA
07/2011 - 03/2011
3Histone Deacetylase InhibitorsIBA
07/2011 - 03/2011
3Androgen Antagonists (Antiandrogens)IBA
08/2008 - 04/2005
3bicalutamide (Casodex)FDA LinkGeneric
08/2008 - 10/2004
3Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
08/2008 - 10/2004
3Estrogen Receptor alphaIBA
06/2008 - 06/2005
3Mitogen-Activated Protein KinasesIBA
06/2008 - 06/2005
2Pharmaceutical PreparationsIBA
03/2015 - 10/2004
2Tyrosine (L-Tyrosine)FDA Link
10/2011 - 10/2006
2Trastuzumab (Herceptin)FDA Link
07/2011 - 03/2011
2SteroidsIBA
01/2011 - 12/2010
2EnzymesIBA
11/2010 - 09/2003
2Proteins (Proteins, Gene)FDA Link
06/2008 - 06/2005
2Tretinoin (Retinoic Acid)FDA LinkGeneric
12/2006 - 12/2004
24-(1H-imidazol-1-yl)retinoic acidIBA
12/2006 - 12/2004
2Estrogen Receptor Modulators (Antiestrogen)IBA
06/2005 - 11/2004
2Fulvestrant (Faslodex)FDA Link
06/2005 - 06/2005
13- hydroxy- 17- (1H- benzimidazole- 1- yl)androsta- 5,16- dieneIBA
03/2015
1abirateroneIBA
11/2011
1Abiraterone AcetateIBA
11/2011
1ErbB Receptors (EGF Receptor)IBA
10/2011
1Epidermal Growth Factor (EGF)IBA
10/2011
1Histone Deacetylases (Histone Deacetylase)IBA
03/2011
1Histones (Histone)IBA
03/2011
1NAD (NADH)IBA
11/2010
1Oxidoreductases (Dehydrogenase)IBA
11/2010
1LigandsIBA
11/2010
1LuciferasesIBA
11/2010
1NF-E2-Related Factor 2IBA
11/2010
1shikoninIBA
11/2010
1quinone (benzoquinone)IBA
11/2010
13beta- hydroxy- 17- (1H- benzimidazole- 1- yl)androsta- 5,16- dieneIBA
08/2008
1Mixed Function Oxygenases (Monooxygenases)IBA
08/2008
1human ERBB2 proteinIBA
06/2008
1Androgen Receptor AntagonistsIBA
01/2008
1Raloxifene Hydrochloride (Evista)FDA Link
01/2007
1Cyclin D1IBA
12/2006
1Phosphotransferases (Kinase)IBA
10/2006
1src-Family KinasesIBA
10/2006
1Carrier Proteins (Binding Protein)IBA
06/2005
1Growth Factor ReceptorsIBA
06/2005
1E 10 (E-10)IBA
04/2005
1Carboxylic AcidsIBA
12/2004
1Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
12/2004
1Growth InhibitorsIBA
12/2004
1exemestane (Aromasin)FDA Link
11/2004
13- hydroxy- 17- (imidazol- 1- yl)androsta- 5,16- dieneIBA
10/2004
13- hydroxy- 17- (1H- 1,2,3- triazol- 1- yl)androsta- 5,16- dieneIBA
10/2004
1Testosterone (Sustanon)FDA Link
10/2004
1Finasteride (Propecia)FDA LinkGeneric
10/2004
1CeramidesIBA
03/2004
1Acid CeramidaseIBA
03/2004

Therapy/Procedure

11Therapeutics
01/2014 - 06/2003
5Castration
03/2015 - 10/2004
1Chemoprevention
11/2010
1Prostatectomy (Retropubic Prostatectomy)
03/2009
1Aftercare (After-Treatment)
03/2004